A human transcription factor in search mode

A human transcription factor in search mode

Transcription factors (TF) can change shape to bind and recognize DNA, shifting the energy landscape from a weak binding, rapid search mode to a higher affinity recognition mode. However, the mechanism(s) driving this conformational change remains unresolved and in most cases high-resolution structures of the non-specific complexes are unavailable. Here, we investigate the conformational switch...

Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer

  Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...

A novel strategy to search conserved transcription factor binding sites among coexpressing genes in human.

We report various transcription factor binding sites (TFBSs) conserved among co-expressed genes in human promoter region using expression and genomic data. Assuming similar promoter structure induces similar transcriptional regulation, hence induces similar expression profile, we compared the promoter structure similarities between co-expressed genes. Comprehensive TF binding site predictions f...

metabolic syndrome and mitochondrial transcription factor a

P-30: The Investigation of Transcript Expression Level of Mitochondrial Transcription Factor A (TFAM) during In Vitro Maturation (IVM) in Single Human Oocytes

Background In vitro maturation (IVM) of human oocytes has acquired increasing attention in infertility treatment with great promise. This technique is an alternative conventional in vitro fertilization-embryo transfer (IVF-ET), and can be reduced the side effects of gonadotropin stimulation such as ovarian hyperstimulation (OHSS). Oocyte maturation is a complex process including cytoplasmic and...